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KRASG12D-IN-4

KRas G12D Inhibitor

KRASG12D-IN-4 is a potent inhibitor of the KRAS G12D mutation, exhibiting an IC50 of 3.3 nM. This compound effectively reduces the proliferation of pancreatic cancer ASPC-1 cells, with an IC50 of 12 nM. KRASG12D-IN-4 serves as a valuable tool in cancer research, particularly for studying the therapeutic potential of targeting KRAS mutations in oncology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3034052-35-9
Applications	KRas G12D Inhibitor
Formula	C₃₅H₃₁F₃N₆O₂
Molecular Weight	624.65
SMILES	CC#CC1=C2C(N3CC4CC(N4)C3)=NC(OC[C@@]56CCCN5C[C@@H](C6)F)=NC2=C(C(C7=CC(O)=CC8=C7C(C#C)=C(C=C8)F)=N1)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.