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KRN-2391

KATP Channel Opener

KRN-2391 is a KATP channel opener that also functions as a nitric oxide (NO) donor. It demonstrates dual inhibitory effects on overactive bladder (OAB) by facilitating the activation of KATP channels, leading to cellular hyperpolarization and relaxation of bladder smooth muscle, while also enhancing relaxation through the cGMP signaling pathway via NO release. KRN-2391 is a valuable tool for research into the mechanisms underlying OAB and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Opener
CAS Number	134431-49-5
Applications	KATP Channel Opener
Formula	C₁₀H₁₃N₅O₆S
Molecular Weight	331.31
SMILES	O=[N+](OCC/N=C(C1=CC=CN=C1)/NC#N)[O-].CS(=O)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.