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Form	MW
KU-0058948 hydrochloride This page	416.88
KU-0058948	380.42

KU-0058948 hydrochloride

PARP1 Inhibitor

KU-0058948 hydrochloride is a highly selective inhibitor of PARP1, exhibiting an IC50 of 3.4 nM. It is demonstrated to induce cell cycle arrest and apoptosis in primary myeloid leukemic cells and various myeloid leukemic cell lines. This reagent is valuable for research into the mechanisms of leukemia and the therapeutic potential of PARP inhibition in hematological malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2108829-86-1
Applications	PARP1 Inhibitor
Formula	C₂₁H₂₂ClFN₄O₂
Molecular Weight	416.88
SMILES	O=C1NN=C(CC2=CC=C(F)C(C(N3CCNCCC3)=O)=C2)C4=C1C=CC=C4.[H]Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.