Fig. 1 · Structure
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Kukoamine B
Active Compound
Kukoamine B, a spermine alkaloid, functions as a dual inhibitor of lipopolysaccharides (LPS) and CpG DNA, exhibiting Kd values of 1.23 µM and 0.66 µM, respectively. This compound demonstrates significant anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic, and neuroprotective properties. Kukoamine B is valuable for research into sepsis and related inflammatory conditions, offering insights into therapeutic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 164991-67-7 |
| Applications | Active Compound |
| Formula | C28H42N4O6 |
| Molecular Weight | 530.66 |
| SMILES | O=C(N(CCCN)CCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.