KUNB106 is a selective inhibitor of Hsp90β, demonstrating binding affinities (KDs) of 91 nM for Hsp90β and 38 μM for Hsp90α. This compound exhibits notable antiproliferative activity against various cancer cell lines, including MDA-MB-231, A549, and SKOV-3, making it a valuable tool for studying triple negative breast cancer. KUNB106's selective inhibition of Hsp90β highlights its potential in oncology research focused on targeted therapies.
KUNB106 is a selective inhibitor of Hsp90β, demonstrating binding affinities (KDs) of 91 nM for Hsp90β and 38 μM for Hsp90α. This compound exhibits notable antiproliferative activity against various cancer cell lines, including MDA-MB-231, A549, and SKOV-3, making it a valuable tool for studying triple negative breast cancer. KUNB106's selective inhibition of Hsp90β highlights its potential in oncology research focused on targeted therapies.
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