Fig. 1 · Structure
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KUNG29
Grp94 Inhibitor
KUNG29 is a selective inhibitor of Grp94, exhibiting a Kd of 0.2 μM, which demonstrates its potent binding affinity. This compound is known to induce the degradation of integrin α2 in MDA-MB-231 cells, highlighting its potential in studying integrin-related pathways and cancer biology. KUNG29 serves as a valuable tool for research applications focused on cellular stress responses and protein homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1887032-92-9 |
| Applications | Grp94 Inhibitor |
| Formula | C22H23ClN2O5 |
| Molecular Weight | 430.88 |
| SMILES | O=C(OC)C1=C(O)C=C(O)C(Cl)=C1CCC2=NC=CN2CC3=CC=CC=C3OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.