Fig. 1 · Structure
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KUNG65
Grp94 Inhibitor
KUNG65 is a selective inhibitor of Grp94, exhibiting a Kd of 540 nM and demonstrating at least 73-fold selectivity over other Hsp90 isoforms. This compound plays a critical role in modulating protein folding and stability within the endoplasmic reticulum. KUNG65 is valuable for research applications focusing on cancer biology, cellular stress responses, and therapeutic interventions targeting Grp94-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2144469-30-5 |
| Applications | Grp94 Inhibitor |
| Formula | C23H20ClFO4 |
| Molecular Weight | 414.85 |
| SMILES | ClC1=C(O)C=C(O)C(C(OC)=O)=C1CCC2=C(CC3=CC=C(F)C=C3)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.