Fig. 1 · Structure
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KuWal151
CLK1/CLK2/CLK4 Inhibitor
KuWal151 is a selective inhibitor of CLK1, CLK2, and CLK4 kinases, demonstrating a significant preference for DYRK kinases. This compound exhibits potent antiproliferative effects across various cultured cancer cell lines, making it a valuable tool for cancer research. Its mechanism of action may provide insights into the role of cyclin-dependent kinases in tumorigenesis and therapeutic resistance. KuWal151 is suitable for studies focused on cancer biology and drug development targeting kinase pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2341841-06-1 |
| Applications | CLK1/CLK2/CLK4 Inhibitor |
| Formula | C16H11ClN2O |
| Molecular Weight | 282.72 |
| SMILES | O=C1NCC2=C1C3=C(C=C2)C(C4=CC=CC(Cl)=C4)=CN3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.