Fig. 1 · Structure
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KW-7158
Afferent Nerve Inhibitor
KW-7158 is a putative afferent nerve inhibitor that targets the nucleoside transporter-1 (ENT1/SLC29A1), functioning as an antagonist for overactive bladder (OAB). This compound demonstrates the ability to depress vesica-vascular reflexes in animal models, making it a valuable tool for studying the mechanisms underlying bladder control and urinary functions. Its role in modulating afferent nerve activity positions KW-7158 as a promising candidate for research in urology and neurobiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 214764-26-8 |
| Applications | Afferent Nerve Inhibitor |
| Formula | C16H12F3NO5S2 |
| Molecular Weight | 419.40 |
| SMILES | FC(F)(F)[C@@](C)(O)C(NC1=C2C(S(=O)(CC3=C(SC=C3)C2=O)=O)=CC=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.