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KWR095

WRN Inhibitor

KWR095 is a potent WRN inhibitor that targets the WRN ATPase with an IC50 value of 0.032 μM. By obstructing the duplex unwinding activity of WRN, KWR095 effectively inhibits the proliferation of tumor cells, demonstrating significant anti-tumor activity. This compound is valuable for research applications focused on cancer biology and the mechanisms of DNA repair.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3057980-16-9
Applications	WRN Inhibitor
Formula	C₃₃H₃₁ClF₃N₉O₄
Molecular Weight	710.11
SMILES	ClC1=CC(C(F)(F)F)=CC=C1NC(CN2C(CC)=C(N3CCN(C(C4=NC=CC5=C4NC=C5)=O)CC3)C(N6C2=NC(C7=CCOCC7)=N6)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.