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L-162537

Angiotensin II Receptor Antagonist

L-162537 is a competitive antagonist of human angiotensin II receptors, specifically targeting receptor 1 (AT1) and receptor 2 (AT2), with an IC50 value of 1.7 nM for AT1. This compound effectively inhibits angiotensin II-mediated vasoconstriction and the associated increase in blood pressure, along with other pathological signaling pathways. L-162537 holds significant potential for research applications focused on angiotensin II-related cardiovascular diseases, including hypertension.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	167027-99-8
Applications	Angiotensin II Receptor Antagonist
Formula	C₃₈H₃₂N₈O₂
Molecular Weight	632.71
SMILES	CCCC1=NC2=C(C(N1CC3=CC=C(C4=C(C5=NNN=N5)C=CC=C4)C=C3)=O)C=C(N(CC6=CN=CC=C6)C(C7=CC=CC=C7)=O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.