Fig. 1 · Structure
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L-162782
AT1 Receptor Ligand
L-162782 is a high-affinity ligand for the angiotensin II type 1 (AT1) receptor, exhibiting IC50 values of 28.5 nM for rat and 24.6 nM for human wild-type AT1. This compound functions as a partial agonist with an EC50 of approximately 30 nM, while also acting as an insurmountable antagonist with an IC50 of 6.5 μM on rat AT1 receptors in COS-7 cells. L-162782 effectively inhibits Angiotensin II-mediated phosphatidylinositol turnover and is valuable for hypertension research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 169281-92-9 |
| Applications | AT1 Receptor Ligand |
| Formula | C32H40N4O4S |
| Molecular Weight | 576.76 |
| SMILES | O=C(OCCCC)NS(=O)(=O)C=1C=CC(=CC1C2=CC=C(C=C2)CN3C4=NC(=CC(=C4N=C3CC)C)C)CC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.