Fig. 1 · Structure
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L-649923
CysLT1 Antagonist
L-649923 is an orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLT1). It has demonstrated efficacy in reducing the incidence of gastritis in animal models of acute gastric mucosal injury. This compound is valuable for research applications related to inflammatory diseases, including asthma and gastritis, providing insights into their underlying mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 114370-57-9 |
| Applications | CysLT1 Antagonist |
| Formula | C25H32O6S |
| Molecular Weight | 460.58 |
| SMILES | OC(C[C@H](C)[C@@H](O)C(C=C1)=CC=C1SCCCOC2=C(C(O)=C(C(C)=O)C=C2)CCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.