L 668411 is a β-lactone compound that acts as an inhibitor of HMG-CoA Reductase (HMGCR), targeting cholesterol biosynthesis. It effectively inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and reduces [14C] acetate incorporation into sterols in Hep G2 cell cultures. The inhibition demonstrates an irreversible mechanism in cellular systems, while exhibiting reversible properties in cultured cells and animal models, making it a valuable tool for studying cholesterol metabolism and related diseases.
L 668411 is a β-lactone compound that acts as an inhibitor of HMG-CoA Reductase (HMGCR), targeting cholesterol biosynthesis. It effectively inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and reduces [14C] acetate incorporation into sterols in Hep G2 cell cultures. The inhibition demonstrates an irreversible mechanism in cellular systems, while exhibiting reversible properties in cultured cells and animal models, making it a valuable tool for studying cholesterol metabolism and related diseases.
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