Fig. 1 · Structure
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L-838417
GABAA Modulator
L-838417 is a selective partial agonist targeting the α2, α3, and α5 subtypes of the GABAA receptor while functioning as an antagonist at the α1 subtype. With binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM, and 2183 nM for various receptor subtypes, L-838417 exhibits significant anti-anxiety effects. This reagent is valuable for research on anxiety disorders and the modulation of GABAergic neurotransmission.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 286456-42-6 |
| Applications | GABAA Modulator |
| Formula | C19H19F2N7O |
| Molecular Weight | 399.41 |
| SMILES | CN1N=CN=C1COC2=NN3C(C=C2C(C)(C)C)=NN=C3C4=CC(F)=CC=C4F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.