L-838417 is a selective partial agonist targeting the α2, α3, and α5 subtypes of the GABAA receptor while functioning as an antagonist at the α1 subtype. With binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM, and 2183 nM for various receptor subtypes, L-838417 exhibits significant anti-anxiety effects. This reagent is valuable for research on anxiety disorders and the modulation of GABAergic neurotransmission.
L-838417 is a selective partial agonist targeting the α2, α3, and α5 subtypes of the GABAA receptor while functioning as an antagonist at the α1 subtype. With binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM, and 2183 nM for various receptor subtypes, L-838417 exhibits significant anti-anxiety effects. This reagent is valuable for research on anxiety disorders and the modulation of GABAergic neurotransmission.
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