Fig. 1 · Structure
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L-Asparagine-d3 hydrate
Stable Isotope
L-Asparagine-d3 hydrate is a deuterated form of the amino acid L-Asparagine, which serves as a substrate for L-Asparaginase, an enzyme crucial for the treatment of leukemia. This stable isotope is instrumental in studying L-Asparaginase's mechanism of action, particularly in depleting asparagine and glutamine levels, thereby inhibiting protein biosynthesis and promoting apoptosis in lymphoblasts. L-Asparagine-d3 hydrate can also function as a biomarker in research related to childhood acute lymphoblastic leukemia, furthering understanding of cancer cell metabolism and therapeutic responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2483831-59-8 |
| Applications | Stable Isotope |
| Formula | C4H7D3N2O4 |
| Molecular Weight | 153.15 |
| SMILES | NC(C([2H])([2H])[C@@](N)([2H])C(O)=O)=O.[H]O[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.