Fig. 1 · Structure
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L-Eflornithine monohydrochloride
Ornithine Decarboxylase Inhibitor
L-Eflornithine monohydrochloride is an irreversible inhibitor of ornithine decarboxylase (ODC), demonstrating a dissociation constant (KD) of 1.3±0.3 µM and a rate constant for inactivation (Kinact) of 0.15±0.03 min-1. This compound effectively inhibits polyamine synthesis, making it valuable for studying cellular proliferation and differentiation processes. L-Eflornithine is utilized in various research applications, including cancer biology and neurobiology, providing insights into the role of polyamines in cellular metabolism and growth regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 69955-42-6 |
| Applications | Ornithine Decarboxylase Inhibitor |
| Formula | C6H13ClF2N2O2 |
| Molecular Weight | 218.63 |
| Synonyms | L-DFMO monohydrochloride; L-RMI71782 monohydrochloride; L-α-difluoromethylornithine monohydrochloride |
| SMILES | N[C@](CCCN)(C(F)F)C(O)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.