Fig. 1 · Structure
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L-Histidinol dihydrochloride
Histidyl-tRNA Synthetase Inhibitor
L-Histidinol dihydrochloride is a potent inhibitor of histidyl-tRNA synthetase, critically involved in protein synthesis initiation. This compound affects cellular proliferation and metabolic processes, making it relevant for cancer research. It has been shown to modulate tumor cell sensitivity to chemotherapeutic agents while potentially reducing toxicity to normal tissues, thereby enhancing the efficacy of cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1596-64-1 |
| Applications | Histidyl-tRNA Synthetase Inhibitor |
| Formula | C6H13Cl2N3O |
| Molecular Weight | 214.10 |
| SMILES | N[C@@H](CC1=CNC=N1)CO.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.