Fig. 1 · Structure
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L-Sepiapterin
Phenylalanine Hydroxylase Activator
L-Sepiapterin is a potent phenylalanine hydroxylase activator that acts as a precursor for the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). This compound enhances endothelial function and promotes angiogenesis, particularly in small mesenteric arteries from db/db mice. Additionally, L-Sepiapterin exhibits inhibitory effects on the proliferation and migration of ovarian cancer cells through down-regulation of p70S6K-dependent VEGFR-2 expression. It is valuable for research focused on hyperphenylalaninemia and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 17094-01-8 |
| Applications | Phenylalanine Hydroxylase Activator |
| Formula | C9H11N5O3 |
| Molecular Weight | 237.22 |
| Synonyms | Sepiapterin |
| SMILES | O=C1NC(N)=NC2=C1N=C(C([C@@H](O)C)=O)CN2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.