L134 is a potent PROTAC BRD4 degrader that targets BRD4 for ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway, demonstrating a DC50 value of 7.36 nM. This compound operates in a DCAF11-dependent manner, making it a valuable tool for studying BRD4-related signaling and therapeutic applications in cancer and other diseases. As a versatile reagent, L134 supports research in targeted protein degradation and the modulation of gene expression pathways.
L134 is a potent PROTAC BRD4 degrader that targets BRD4 for ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway, demonstrating a DC50 value of 7.36 nM. This compound operates in a DCAF11-dependent manner, making it a valuable tool for studying BRD4-related signaling and therapeutic applications in cancer and other diseases. As a versatile reagent, L134 supports research in targeted protein degradation and the modulation of gene expression pathways.
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