Fig. 1 · Structure
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L48H37
MD2 Inhibitor
L48H37 is a selective inhibitor of myeloid differentiation protein 2 (MD2), which plays a critical role in the signaling pathway of lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4). This compound demonstrates strong inhibitory activity against the LPS-TLR4/MD2 interaction, making it a valuable tool for investigating inflammatory responses. L48H37 is particularly applicable in research related to sepsis and lung injury therapies, where modulation of this pathway could offer therapeutic benefits. Its enhanced chemical stability compared to Curcumin further supports its use in experimental settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 343307-76-6 |
| Applications | MD2 Inhibitor |
| Formula | C27H33NO7 |
| Molecular Weight | 483.55 |
| SMILES | O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC)CC)=C/C3=CC(OC)=C(C(OC)=C3)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.