Fig. 1 · Structure
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L524-0366
TWEAK-Fn14 Inhibitor
L524-0366 is a specific TWEAK-Fn14 inhibitor that competitively binds to the Fn14 receptor with a dissociation constant (KD) of 7.12 μM, effectively blocking TWEAK's interaction with Fn14. This compound demonstrates a significant inhibition rate of 16% in TWEAK-Fn14 binding and has been shown to inhibit TWEAK-induced glioma cell migration while displaying minimal cytotoxicity. L524-0366 serves as a valuable tool for research in cancer biology and therapeutic strategies targeting glioma progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 951612-19-4 |
| Applications | TWEAK-Fn14 Inhibitor |
| Formula | C13H13ClN4OS |
| Molecular Weight | 308.79 |
| SMILES | O=C(N1CCSCC1)C2=CN(N=N2)C3=CC=CC(Cl)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.