Fig. 1 · Structure
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L57
LRP1 Agonist
L57 is an LRP1 agonist that binds with high affinity to low-density lipoprotein receptor-related protein 1, exhibiting an EC50 of 45 nM. This peptide demonstrates significant blood-brain barrier permeability and enhanced plasma stability, making it a valuable candidate for therapeutic applications in central nervous system drug delivery. L57 is particularly useful for research focused on neuropharmacology and drug transport mechanisms across the blood-brain barrier.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2378836-93-0 |
| Applications | LRP1 Agonist |
| Formula | C120H175N31O27 |
| Molecular Weight | 2483.87 |
| SMILES | C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC7=CN=CN7)C(O)=O)=O)CCCCN)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)[C@H](CC)C)=O)CO)=O)=O)=O)[C@@H](C)O)=O)=O)CCCCN)=O)CC(O)=O)=O)=O)=O)CCCCN)=O)CCC1)NC([C@H]([C@@H](C)O)N)=O)C=8C=9C(NC8)=CC=CC9 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.