Fig. 1 · Structure
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L82-G17
Lig I Inhibitor
L82-G17 is an uncompetitive inhibitor of DNA ligase I (Lig I), specifically targeting the third step of the ligation reaction, which involves phosphodiester bond formation. This compound effectively disrupts the ligation process, making it a valuable tool for probing the catalytic activity of DNA ligases in various research applications. Its selective inhibition can aid in studies related to DNA repair mechanisms and recombinant DNA technology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 92285-87-5 |
| Applications | Lig I Inhibitor |
| Formula | C11H9ClN4O2 |
| Molecular Weight | 264.67 |
| SMILES | O=C1NN=CC(N/N=C/C2=CC(O)=CC=C2)=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.