Fig. 1 · Structure
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Landiolol hydrochloride
adrenoceptor antagonist
Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min), acts as an adrenoceptor antagonist.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 144481-98-1 |
| Applications | adrenoceptor antagonist |
| Formula | C25H40ClN3O8 |
| Molecular Weight | 546.05 |
| Synonyms | ONO1101 hydrochloride; ONO 1101 |
| SMILES | O=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 89 mg/mL (162.99 mM) |
| Water | 89 mg/mL (162.99 mM) |
| Ethanol | 37 mg/mL (67.75 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.