Fig. 1 · Structure
Documents & Downloads
Larotinib mesylate hydrate
Tyrosine Kinase Inhibitor
Larotinib mesylate hydrate is a potent orally bioavailable tyrosine kinase inhibitor (TKI) primarily targeting the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.6 nM. This compound demonstrates significant inhibitory activity against various cancer-associated signaling pathways, making it a valuable tool in cancer research. Its application includes studying the effects of EGFR modulation and investigating potential therapeutic strategies in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2097129-93-4 |
| Applications | Tyrosine Kinase Inhibitor |
| Formula | C26H36ClFN4O11S2 |
| Molecular Weight | 699.17 |
| SMILES | COC(C(OCCCN1C[C@]2([H])[C@](OCCO2)([H])C1)=C3)=CC4=C3C(NC5=CC(Cl)=C(C=C5)F)=NC=N4.CS(=O)(O)=O.CS(=O)(O)=O.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.