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LAS190792

Muscarinic Antagonist/β2-adrenoceptor Agonist

LAS190792 is a potent muscarinic antagonist and β2-adrenoceptor agonist, exhibiting high affinity with pIC50 values of 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, and 5.6 for M1, M2, M3, M4, M5, β1, β2, and β3 receptors, respectively. This compound is primarily utilized as a bronchodilator in respiratory research, demonstrating significant potential in the treatment of conditions such as asthma and chronic obstructive pulmonary disease (COPD). Its dual action enhances airway relaxation and improves respiratory function.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1347232-69-2
Applications	Muscarinic Antagonist/β2-adrenoceptor Agonist
Formula	C₃₉H₄₃ClN₄O₉S₂
Molecular Weight	811.36
Synonyms	AZD8999
SMILES	COC(C=C(NC(OCCN(C)[C@@H]1CC[C@@H](OC(C(O)(C2=CC=CS2)C3=CC=CS3)=O)CC1)=O)C(Cl)=C4)=C4CNC[C@H](O)C5=CC=C(O)C(N6)=C5C=CC6=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.