Fig. 1 · Structure
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(-)-Latifolin
Apoptotic Inducer
(-)-Latifolin is a flavonoid that acts as an apoptotic inducer by specifically targeting the PI3K/AKT/mTOR/p70S6K signaling pathway. It demonstrates significant inhibition of cell proliferation in oral squamous cell carcinoma (OSCC) and exhibits anti-metastatic properties by obstructing cell migration, invasion, and adhesion through the inactivation of FAK/Src. Additionally, (-)-Latifolin suppresses autophagy-related protein expression and autophagosome formation while inhibiting necroptosis via dephosphorylation of key regulatory proteins such as RIP1, RIP3, and MLKL. This compound also shows potential therapeutic applications in anti-aging, anti-carcinogenic, anti-inflammatory, and cardioprotective research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 10154-42-4 |
| Applications | Apoptotic Inducer |
| Formula | C17H18O4 |
| Molecular Weight | 286.32 |
| SMILES | OC1=CC([C@@H](C2=CC=CC=C2O)C=C)=C(OC)C=C1OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.