Fig. 1 · Structure
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Latrepirdine
Amyloid-β Inhibitor
Latrepirdine is an amyloid-β inhibitor that promotes the catabolism of amyloid precursor protein (APP) while decreasing amyloid-β (Aβ) secretion. This neuroactive compound exhibits antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine is primarily utilized in research focused on Alzheimer’s disease and other neurodegenerative conditions, making it a valuable tool for investigating mechanisms of amyloid pathology and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3613-73-8 |
| Applications | Amyloid-β Inhibitor |
| Formula | C21H25N3 |
| Molecular Weight | 319.44 |
| Synonyms | Dimebolin; Dimebone |
| SMILES | CC1=CC=C(CCN2C3=C(CN(C)CC3)C4=C2C=CC(C)=C4)C=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.