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LBA-3

SLC13A5 Inhibitor

LBA-3 is a selective, orally bioavailable inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibiting an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in oleic and palmitic acid-stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, demonstrating efficacy in mouse models without observable toxicity. Additionally, LBA-3 is capable of crossing the blood-brain barrier, making it a valuable tool for investigating metabolic disorders and related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2918263-09-7
Applications	SLC13A5 Inhibitor
Formula	C₁₈H₁₈O₅
Molecular Weight	314.33
SMILES	O=C(C(CCC1=CC=C(C=C1)C2=CC=CC=C2)(CC(O)=O)O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.