Fig. 1 · Structure
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LBT-999
Dopamine Transporter
LBT-999 is a phenyltropane derivative that specifically targets the dopamine transporter (DAT). This compound exhibits high-affinity binding to DAT in rat striatal membranes and human postmortem brain slices in vitro. In vivo studies demonstrate significant uptake in the striatum of rat and baboon models, and its binding affinity can be inhibited by selective compounds. LBT-999 is valuable for research applications in neuroimaging, particularly in positron emission tomography (PET) studies of dopaminergic function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 877467-20-4 |
| Applications | Dopamine Transporter |
| Formula | C20H26FNO2 |
| Molecular Weight | 331.42 |
| SMILES | COC([C@@H]1[C@]2([H])N([C@](CC2)([H])C[C@@H]1C3=CC=C(C=C3)C)C/C=C/CF)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.