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LC-2 epimer

Catalog No.: A63734
PROTAC Degrader
LC-2 epimer is a differential isomer of LC-2, functioning as a PROTAC degrader. This compound selectively targets mutant KRAS through its unique linkage of a von Hippel-Lindau (VHL) E3 ligase ligand and the KRAS inhibitor MRTX849. LC-2 epimer is intended for research applications focused on targeted protein degradation and the study of KRAS-related pathways in cancer.
LC-2 epimer 2502156-12-7 PROTAC Degrader
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Size Price Stock Qty
1mg
$1,585.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLC-2 epimer is a differential isomer of LC-2, functioning as a PROTAC degrader. This compound selectively targets mutant KRAS through its unique linkage of a von Hippel-Lindau (VHL) E3 ligase ligand and the KRAS inhibitor MRTX849. LC-2 epimer is intended for research applications focused on targeted protein degradation and the study of KRAS-related pathways in cancer.
Product Information
Catalog NumA63734
FormulaC59H71ClFN11O7S
Molecular Weight1132.78
CAS Number2502156-12-7
SMILESO=C(N1[C@@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCCN(CCC4)[C@@H]4COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(C8=CC=CC9=C8C(Cl)=CC=C9)CC7)=N5)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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PROTAC > PROTAC Degrader