Fig. 1 · Structure
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LC kinetic stabilizer-1
Light Chain Kinetic Stabilizer
LC Kinetic Stabilizer-1 is a potent and selective light chain kinetic stabilizer targeting amyloidogenic immunoglobulins. It demonstrates effective inhibition with EC50 values of 140 nM for WIL-FL and 74.1 nM for the WIL-FL T46L/F49Y variant. This compound is essential for research into the molecular mechanisms of amyloidogenesis and may aid in the development of therapeutic strategies for related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Stabilizer |
| CAS Number | 2495750-19-9 |
| Applications | Light Chain Kinetic Stabilizer |
| Formula | C27H31N5O3 |
| Molecular Weight | 473.57 |
| SMILES | O=C1OC2=CC(N(CC)CC)=CC=C2C(C)=C1CCNC(NCC3=CC(C4=CNC=N4)=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.