Fig. 1 · Structure

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LC3 liagnd-2

Ligands for E3 Ligase

LC3 ligand-2 is a ligand for E3 ligases that facilitates targeted protein degradation through the PROTAC system. This compound is utilized in the synthesis of PROTAC PDEδ autophagic degrader 1, providing a valuable tool for researchers studying autophagy and protein homeostasis. Its application extends to the development of novel therapeutic strategies for diseases associated with protein misfolding and aggregation.

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Specifications

Manufacturer Adooq Bioscience
Actions Ligand / Binder
CAS Number 2839637-57-7
Applications Ligands for E3 Ligase
Formula C17H10Br2INO4
Molecular Weight 578.98
SMILES
O=C(O)COC1=C(Br)C=C(/C=C2C(NC3=C\2C=C(I)C=C3)=O)C=C1Br

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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