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LCB-2151

Anticancer Agent

LCB-2151 is a nucleoside analogue that acts as an anticancer agent by disrupting ATP production pathways, specifically glycolysis and mitochondrial oxidative phosphorylation. This mechanism significantly compromises the energy metabolism of KRAS-mutated pancreatic cancer cells, leading to reactive oxygen species (ROS) formation and enhanced cytotoxicity. LCB-2151 also inhibits critical enzymes involved in glycolysis, the TCA cycle, and fatty acid β-oxidation, promoting cellular apoptosis. This compound is applicable in research focused on enhancing radiation therapy efficacy in cancer treatment.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2211175-99-2
Applications	Anticancer Agent
Formula	C₃₇H₄₃F₈N₃O₅S₂
Molecular Weight	825.87
SMILES	OC[C@@]1(C)C(F)(F)[C@H](N2C(N=C(NC(CC(C)(C)CC[C@@H](SCC3=CC=C(C(F)(F)F)C=C3)CCSCC4=CC=C(C(F)(F)F)C=C4)=O)C=C2)=O)O[C@@H]1CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.