LCKLSL is an N-terminal hexapeptide that functions as a competitive inhibitor of annexin A2 (AnxA2). It effectively blocks the interaction between tissue plasminogen activator (tPA) and AnxA2, thereby inhibiting plasmin generation. Through suppression of the tPA–AnxA2–plasmin pathway, LCKLSL exhibits significant anti-angiogenic activity and may serve as a valuable tool for studying AnxA2-mediated fibrinolytic and vascular processes.
LCKLSL is an N-terminal hexapeptide that functions as a competitive inhibitor of annexin A2 (AnxA2). It effectively blocks the interaction between tissue plasminogen activator (tPA) and AnxA2, thereby inhibiting plasmin generation. Through suppression of the tPA–AnxA2–plasmin pathway, LCKLSL exhibits significant anti-angiogenic activity and may serve as a valuable tool for studying AnxA2-mediated fibrinolytic and vascular processes.
Product Information
Catalog Num
A24552
Formula
C30H57N7O8S
Molecular Weight
675.88
CAS Number
533902-29-3
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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