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LCZ960

Glucokinase Activator

LCZ960 is an orally active glucokinase (GK) activator that enhances GK activity in hepatocytes in vitro and promotes glucose uptake in vivo. This compound effectively lowers blood glucose levels in diet-induced obesity (DIO) models, helping to maintain normoglycemia and improve glucose tolerance in both mice and rats. Additionally, LCZ960 stimulates glycogen synthase activity and enhances hepatic glycogen turnover, making it a valuable tool for researchers studying high-fat diet-induced obesity and type 2 diabetes mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	1067877-83-1
Applications	Glucokinase Activator
Formula	C₃₀H₃₄N₆O₃S₂
Molecular Weight	590.76
Synonyms	NVP-LCZ960
SMILES	O=S(C(C=C1)=CC=C1[C@@H](CC2CCCC2)C(NC3=NC4=CC=C(C5=CC=NC=C5)N=C4S3)=O)(N6CCN(CC6)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.