Fig. 1 · Structure
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LDC7559
GSDMD Inhibitor
LDC7559 is an inhibitor of gasdermin D (GSDMD), specifically targeting the pathways involved in the formation of neutrophil extracellular traps (NETs) during the late stages of cellular activation. This compound effectively disrupts GSDMD's role in pyroptosis and inflammation, making it a valuable tool for research into immune responses, inflammatory diseases, and cell death mechanisms. Its use can facilitate a deeper understanding of GSDMD's contributions to pathological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2407782-01-6 |
| Applications | GSDMD Inhibitor |
| Formula | C20H19N3O3 |
| Molecular Weight | 349.38 |
| SMILES | COC1=C(C=CC=C1)C2=NN3C(COC(C=C(NC(C)=O)C=C4)=C4C3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.