Fig. 1 · Structure
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Lecimibide
ACAT Inhibitor
Lecimibide is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. This compound demonstrates significant antihyperlipidemic activity, making it valuable for research into lipid disorders and cardiovascular diseases. Lecimibide can be utilized in studies focusing on the modulation of cholesterol levels and the exploration of therapeutic strategies for hyperlipidemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 130804-35-2 |
| Applications | ACAT Inhibitor |
| Formula | C34H40F2N4OS |
| Molecular Weight | 590.77 |
| Synonyms | DuP 128 |
| SMILES | O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.