Lecozotan hydrochloride

Catalog No.: A46014
5-HT1A Antagonist
Lecozotan hydrochloride is a selective antagonist of the 5-HT1A receptor, exhibiting a Ki of 4.5 nM for the cloned human receptor. This compound enhances the stimulated release of glutamate and acetylcholine in the hippocampus, demonstrating cognitive-enhancing properties. Lecozotan hydrochloride is a valuable tool for research into mild-to-moderate Alzheimer's disease (AD) and other cognitive disorders.
Grouped product items
Size Price Stock Qty
1mg
$110.00
In stock
5mg
$275.00
In stock
10mg
$450.00
In stock
25mg
$720.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLecozotan hydrochloride is a selective antagonist of the 5-HT1A receptor, exhibiting a Ki of 4.5 nM for the cloned human receptor. This compound enhances the stimulated release of glutamate and acetylcholine in the hippocampus, demonstrating cognitive-enhancing properties. Lecozotan hydrochloride is a valuable tool for research into mild-to-moderate Alzheimer's disease (AD) and other cognitive disorders.
Product Information
Catalog NumA46014
FormulaC28H30ClN5O3
Molecular Weight520.02
CAS Number433282-68-9
SMILESO=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl
SynonymsSRA-333 hydrochloride
Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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