Lecozotan hydrochloride is a selective antagonist of the 5-HT1A receptor, exhibiting a Ki of 4.5 nM for the cloned human receptor. This compound enhances the stimulated release of glutamate and acetylcholine in the hippocampus, demonstrating cognitive-enhancing properties. Lecozotan hydrochloride is a valuable tool for research into mild-to-moderate Alzheimer's disease (AD) and other cognitive disorders.
Lecozotan hydrochloride is a selective antagonist of the 5-HT1A receptor, exhibiting a Ki of 4.5 nM for the cloned human receptor. This compound enhances the stimulated release of glutamate and acetylcholine in the hippocampus, demonstrating cognitive-enhancing properties. Lecozotan hydrochloride is a valuable tool for research into mild-to-moderate Alzheimer's disease (AD) and other cognitive disorders.
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