Fig. 1 · Structure
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Lecozotan hydrochloride
5-HT1A Antagonist
Lecozotan hydrochloride is a selective antagonist of the 5-HT1A receptor, exhibiting a Ki of 4.5 nM for the cloned human receptor. This compound enhances the stimulated release of glutamate and acetylcholine in the hippocampus, demonstrating cognitive-enhancing properties. Lecozotan hydrochloride is a valuable tool for research into mild-to-moderate Alzheimer's disease (AD) and other cognitive disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 433282-68-9 |
| Applications | 5-HT1A Antagonist |
| Formula | C28H30ClN5O3 |
| Molecular Weight | 520.02 |
| Synonyms | SRA-333 hydrochloride |
| SMILES | O=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.