Fig. 1 · Structure
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LEM-14-1189
NSD Inhibitor
LEM-14-1189 is an NSD inhibitor that targets histone lysine methyltransferases (HMTases), specifically NSD1, NSD2, and NSD3, with IC50 values of 418 μM, 111 μM, and 60 μM, respectively. NSDs play a crucial role as oncoproteins in tumorigenesis, making LEM-14-1189 a valuable tool for investigating multiple myeloma (MM) and other related cancers. This compound aids in elucidating the mechanisms of NSD-mediated pathways and their impact on tumor progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2987501-17-5 |
| Applications | NSD Inhibitor |
| Formula | C35H34N6O5S2 |
| Molecular Weight | 682.81 |
| SMILES | O=C(C(OC1=O)=CC2=C1C=CC=C2)NCCCN(CC3=NC4=C(C5=C(CCCC5)S4)C(N3)=O)CC6=NC7=C(C8=C(CCCC8)S7)C(N6)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.