Fig. 1 · Structure
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LEM-14
NSD2 Inhibitor
LEM-14 is a selective inhibitor of NSD2, demonstrating an IC50 of 132 µM. It shows minimal activity against NSD1 and lacks activity towards NSD3. This compound effectively inhibits fibrotic gene expression in non-diabetic bone marrow-derived macrophages (BMDMs) and, when used in combination with ionizing radiation, enhances apoptosis rates and reduces colony formation in colorectal cancer cells. Additionally, LEM-14 has been shown to improve anti-tumor efficacy in Balb/c nude mice with LoVo cell xenografts, making it a promising candidate for research into multiple myeloma and colorectal cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1814881-70-3 |
| Applications | NSD2 Inhibitor |
| Formula | C25H26N4O4S |
| Molecular Weight | 478.56 |
| SMILES | O=C1C(C2=C(CCCC2)S3)=C3NC(CN4CCN(C([C@H]5CC6=CC=CC=C6C(O5)=O)=O)CC4)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.