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Lemzoparlimab
Lemzoparlimab (TJ011133; TJC4) is a humanized IgG4 monoclonal antibody targeting CD47. This antibody exhibits potent antitumor activity, making it a valuable tool for research in cancer immunotherapy. Lemzoparlimab functions by engaging with the CD47 protein, a key regulator in the 'don't eat me' signal that protects cancer cells from macrophage-mediated phagocytosis. By blocking this signal, Lemzoparlimab promotes the phagocytosis of malignant cells, thereby facilitating an immune response against the tumor. This mechanism highlights its potential utility in studies focused on tumor immunity and therapeutic antibody development.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2377483-71-9 |
| Molecular Weight | 145580 |
| Synonyms | TJ011133; TJC4 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.