Fig. 1 · Structure
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Lenalidomide 4'-PEG1-amine dihydrochloride
Ligands for E3 Ligase
Lenalidomide 4'-PEG1-amine dihydrochloride serves as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, enabling the development of proteolysis-targeting chimeras (PROTACs). Researchers can utilize this reagent to explore targeted protein degradation pathways and investigate potential therapeutic applications in various cancers and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2624336-86-1 |
| Applications | Ligands for E3 Ligase |
| Formula | C17H24Cl2N4O4 |
| Molecular Weight | 419.30 |
| SMILES | O=C1NC(C(CC1)N2C(C3=C(C2)C(NCCOCCN)=CC=C3)=O)=O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.