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Lenalidomide-amide-C8-Br

CRBN Ligand-Linker Conjugate

Lenalidomide-amide-C8-Br is a CRBN ligand-linker conjugate that incorporates Lenalidomide and a C8 linker. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs), specifically enabling the synthesis of the PI3Kα/δ degrader-1. Its unique composition positions it as a valuable tool for research focused on targeted protein degradation and the exploration of E3 ligase-mediated pathways.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2580972-35-4
Applications	CRBN Ligand-Linker Conjugate
Formula	C₂₂H₂₈BrN₃O₄
Molecular Weight	478.38
SMILES	O=C1NC(C(CC1)N2C(C3=C(C2)C(NC(CCCCCCCCBr)=O)=CC=C3)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.