Fig. 1 · Structure
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Lenalidomide-propargyl-C2-NH2 hydrochloride
E3 Ligase Ligand-Linker Conjugates
Lenalidomide-propargyl-C2-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a cereblon (CRBN) ligand, enabling targeted ubiquitination via the E3 ubiquitin ligase pathway. This compound serves as a critical component in the design of the PROTAC MD-224, facilitating targeted protein degradation. Additionally, Lenalidomide-propargyl-C2-NH2 hydrochloride functions as a click chemistry reagent, characterized by its alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it valuable for research applications focused on protein modulation and degradation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2489242-23-9 |
| Applications | E3 Ligase Ligand-Linker Conjugates |
| Formula | C18H20ClN3O3 |
| Molecular Weight | 361.82 |
| SMILES | O=C(C(N(CC1=C2C=CC=C1C#CCCCN)C2=O)CC3)NC3=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.