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Fig. 1 · Structure
Cat. No.
A16796
CAS No.
1354690-24-6
Formula
C21H25F3N6O2
Mol. Weight
450.46

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Leniolisib (CDZ 173)

Cat. No. A16796 CAS 1354690-24-6

PI3K inhibitor

Leniolisib(CDZ 173) is a potent PI3Kδ selective inhibitor with biochemical IC50 values of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.

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Biological Activity

Target & Activity

Target Activity Value
PI3Kδ IC50 11 nM
PI3Kα IC50 280 nM
PI3Kβ IC50 480 nM
PI3Kγ IC50 2.57 μM
DNA-PK IC50 880 nM

Cellular Effect

Cell Line Activity Value Description Reference
DOHH-2 IC50 29.2 μM Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]
JeKo-1 IC50 31.66 μM Antiproliferative activity against human JeKo-1 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]
Pfeiffer IC50 3.75 μM Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]
Rec1 IC50 1.28 μM Antiproliferative activity against human REC1 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]
SUD4 IC50 8.25 μM Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]
SU-DHL-6 IC50 0.77 μM Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]
Z-138 IC50 31.19 μM Antiproliferative activity against human Z138 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay [PMID: 35609190]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1354690-24-6
Applications PI3K inhibitor
Formula C21H25F3N6O2
Molecular Weight 450.46
Synonyms CDZ-173; Leniosilib
SMILES
FC(C1=C(OC)N=CC(N(CCC2=NC=N3)CC2=C3N[C@@H]4CN(C(CC)=O)CC4)=C1)(F)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 81 mg/mL (179.81 mM)
Water Insoluble
Ethanol 12 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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