Fig. 1 · Structure
Documents & Downloads
Leptomycin A
CRM1 Inhibitor
Leptomycin A is a potent CRM1 (exportin 1) inhibitor that disrupts the interaction between CRM1 and nuclear export signals, thereby impeding the nuclear export of various proteins. This compound has demonstrated the ability to suppress HIV-1 replication, making it valuable for research in virology and cellular transport mechanisms. Leptomycin A is considered less potent than its analogue, Leptomycin B, and is commonly utilized in studies investigating nuclear-cytoplasmic trafficking and antiviral strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 87081-36-5 |
| Applications | CRM1 Inhibitor |
| Formula | C32H46O6 |
| Molecular Weight | 526.70 |
| SMILES | O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(C)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.