Leptomycin B

Catalog No.: A20985

nuclear export receptor CRM1 inhibitor

Leptomycin B

Leptomycin B Chemical Structure

CAS NO. 87081-35-4

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.49 mL 92.47 mL 184.94 mL
0.5 mM 3.7 mL 18.49 mL 36.99 mL
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20985
Actions Inhibitor
M. Wt 540.73
Formula C33H48O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 87081-35-4
Synonyms CI 940, CI940, CI-940; LMB
SMILES O=C(O)/C=C(C)/C[[email protected]](C)[[email protected]@H](O)[[email protected]](C)C([[email protected]](C)/C=C(C)/C=C/C[[email protected]@H](C)/C=C(CC)\C=C\[[email protected]]1[[email protected]@H](C)C=CC(O1)=O)=O

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