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Lepunafusp alfa

BBB-Penetrable Fusion Protein

Lepunafusp alfa is a blood-brain barrier (BBB)-penetrable fusion protein that combines J-Brain Cargo with IDUA, a lysosomal enzyme responsible for α-L-iduronidase activity. This compound effectively reduces concentrations of heparan sulfate (HS) and dermatan sulfate (DS), making it a valuable tool for investigating mucopolysaccharidosis type I. Its unique ability to cross the BBB facilitates research into therapeutic strategies for lysosomal storage disorders and related neurological conditions.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2396411-71-3
Applications	BBB-Penetrable Fusion Protein
Synonyms	JR-171

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.